Burkina Faso is situated in the Sahel where the dry season lasts nine months without interruption. The population uses open wells that often dry up and the women are forced to use unhealthy water collected in artificial ponds during the rainy season. Sometimes they have to go as far as ten kilometres in order to find water and the rare wells that do exist become a source of conflict because of the scarcity of water and the long time they have to wait. Operation Hope supports the drilling of wells and the installation of pumps. These wells are an essential source of water supply for the people and for the prevention of sickness.

In 2010, Operation Hope also supported a project to provide milk for children at the hospital of Nanoro, also in Burkina-Faso.

In 2021, Operation Hope supported a project to create an agro-pastoral farm in Koubri (breeding pigs and laying hens) as well as an agricultural production field (papayas, citrus fruits and potatoes). This project aims to act on several levels: combating poverty, promoting modern agricultural and livestock techniques, creating jobs for young people and ensuring food self-sufficiency. The project is led by three young agricultural engineers, Father Noël (from the Saint Vincent de Paul religious order in West Africa), with the support of the mayor of Koubri.